Characterization of the human tear metabolome by LC-MS/MS.

  title={Characterization of the human tear metabolome by LC-MS/MS.},
  author={Liyan Chen and Lei Zhou and Eric Chun Yong Chan and Jason Gek Leong Neo and Roger W. Beuerman},
  journal={Journal of proteome research},
  volume={10 10},
The tear film overlying the epithelial cells of the eye's surface is vital to visual function, and its composition is reflective of ocular surface health. The ultrasmall volume of tears poses challenges in its analysis, contributing to the limited number of reports on the tear metabolome. In addition, using a standard clinical method of tear collection posed some confounding factors in metabonomic analysis. We sought to establish an analytical platform for the global characterization of human… CONTINUE READING