Characterization of the human p53 gene promoter.

@article{Tuck1989CharacterizationOT,
  title={Characterization of the human p53 gene promoter.},
  author={Simon P. Tuck and L. Lucille Crawford},
  journal={Molecular and cellular biology},
  year={1989},
  volume={9 5},
  pages={
          2163-72
        }
}
Transcriptional deregulation of the p53 gene may play an important part in the genesis of some tumors. We report here an accurate determination of the transcriptional start sites of the human p53 gene and show that the majority of p53 mRNA molecules do not contain a postulated stem-loop structure at their 5' ends. Recombinant plasmids of the human p53 promoter-leader region fused to the bacterial chloramphenicol acetyltransferase gene (cat) were constructed. After transfection into rodent or… CONTINUE READING
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