Characterization of the human homolog of the IL-4 induced gene-1 (Fig1).

@article{Chavan2002CharacterizationOT,
  title={Characterization of the human homolog of the IL-4 induced gene-1 (Fig1).},
  author={Sangeeta S Chavan and Wenzhi Tian and Kevin Hsueh and Damini Jawaheer and Peter K. Gregersen and Charles C Chu},
  journal={Biochimica et biophysica acta},
  year={2002},
  volume={1576 1-2},
  pages={70-80}
}
Mouse interleukin-four induced gene-1 (mFig1) maps to a region of susceptibility for systemic lupus erythematosus (SLE) that includes the Sle3 locus. To begin examining this relationship in humans, we have isolated and characterized the human homolog of mFig1. Human Fig1 (hFig1) has the same eight exon genomic structure as mFig1. The predicted 63-kDa protein, like mFig1, contains a signal peptide, a large internal sequence that is most similar (43% identical over 484 amino acids) to L-amino… CONTINUE READING

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Finally , hFig1 maps to the predicted mFig1 syntenic region on human chromosome 19q13.3 - 19q13.4 , a hot spot for susceptibility to several autoimmune diseases , including SLE .
When compared to the LAAO crystal structure , hFig1 conserves key residues thought to be involved in catalysis and binding of the flavin adenine dinucleotide cofactor .
Finally , hFig1 maps to the predicted mFig1 syntenic region on human chromosome 19q13.3 - 19q13.4 , a hot spot for susceptibility to several autoimmune diseases , including SLE .
Finally , hFig1 maps to the predicted mFig1 syntenic region on human chromosome 19q13.3 - 19q13.4 , a hot spot for susceptibility to several autoimmune diseases , including SLE .
When compared to the LAAO crystal structure , hFig1 conserves key residues thought to be involved in catalysis and binding of the flavin adenine dinucleotide cofactor .
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