Characterization of the human hepatocellular carcinoma (HEPG2) cell line as an in vitro model for cadmium toxicity studies

@article{Dehn2004CharacterizationOT,
  title={Characterization of the human hepatocellular carcinoma (HEPG2) cell line as an in vitro model for cadmium toxicity studies},
  author={P. F. Dehn and Caitlin M. White and Deanna E Conners and G. Shipkey and Thomas A Cumbo},
  journal={In Vitro Cellular & Developmental Biology - Animal},
  year={2004},
  volume={40},
  pages={172-182}
}
Biochemical indicators and in vitro models, if they mimic in vivo responses, offer potentially sensitive tools for inclusion in toxicity assessment programs. The purpose of this study was to determine whether the HepG2 cell line would mimic known in vivo or in vitro (or both) responses of mammalian systems when confronted with cadmium (Cd2+). Uptake and compartmentalization of Cd2+, metallothionein (MT) compartmentalization, and glutathione (GSH) depletion were examined. In addition, several… CONTINUE READING