Characterization of the human cell line TE671.

  title={Characterization of the human cell line TE671.},
  author={Michael R. Stratton and John Darling and Geoffrey J. Pilkington and Peter L. Lantos and Brandy Reeves and Colin S Cooper},
  volume={10 5},
The cell line TE671 has been widely used as a model of human medulloblastoma. In the present study we have demonstrated that transfection of DNA from this cell line into NIH 3T3 cells reveals the presence of an activated N-ras gene. Using oligonucleotide probes we have shown that the N-ras gene is activated by a point mutation at the third base of codon 61 resulting in the substitution of histidine for glutamine in the p21 ras gene product. We noted that this relatively uncommon activating… CONTINUE READING
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