Characterization of the human MATE2 proton-coupled polyspecific organic cation exporter.

@article{Komatsu2011CharacterizationOT,
  title={Characterization of the human MATE2 proton-coupled polyspecific organic cation exporter.},
  author={Toshinori Komatsu and Miki Hiasa and Takaaki Miyaji and Takuji Kanamoto and Takuya Matsumoto and Masato Otsuka and Yoshinori Moriyama and Hiroshi Omote},
  journal={The international journal of biochemistry & cell biology},
  year={2011},
  volume={43 6},
  pages={913-8}
}
Human multidrug and toxic compound extrusion 2 (hMATE2) is a kidney-specific isoform of hMATE1, an exporter of toxic organic cations (OCs) of exogenous and endogenous origins at the final excretion step in the kidneys and liver (Otsuka et al., 2005), and contains a splicing variant, MATE2K, that has an exon of hMATE2 deleted (Masuda et al., 2006). In the present study, we characterized the degree of expression and the transport properties of hMATE2. Quantitative PCR analysis with probes… CONTINUE READING
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