Characterization of the human 5-hydroxytryptamine1B receptor.

  title={Characterization of the human 5-hydroxytryptamine1B receptor.},
  author={H Jin and Donna Oksenberg and Avi Ashkenazi and Stephen J. Peroutka and A. M. Duncan and Richard F. Rozmahel and Yinshan Yang and Guadalupe Mengod and Juan Manuel Palacios and Brian F O'dowd},
  journal={The Journal of biological chemistry},
  volume={267 9},
We report the cloning of a human gene encoding the 5-hydroxytryptamine1B receptor. The receptor has the characteristics of a G-protein-linked receptor and is most homologous to the human 5-HT1D receptor. This human 5-HT receptor gene, most abundantly expressed in striatum, is localized on chromosome 6, at 6q13, and the gene encoding the 5-HT1D receptor is localized on chromosome 1. Radioligand studies indicate that the affinity of [3H]5-HT is 16 +/- 2 nM. Drug competition studies indicate that… CONTINUE READING

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