Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes.

@article{Brer1999CharacterizationOT,
  title={Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes.},
  author={Stefan Br{\"o}er and Angelika Br{\"o}er and H. P. G. Schneider and Carola Stegen and Andrew Philip Halestrap and Joachim W. Deitmer},
  journal={The Biochemical journal},
  year={1999},
  volume={341 ( Pt 3)},
  pages={529-35}
}
Observations on lactate transport in brain cells and cardiac myocytes indicate the presence of a high-affinity monocarboxylate transporter. The rat monocarboxylate transporter isoform MCT2 was analysed by expression in Xenopus laevis oocytes and the results were compared with the known characteristics of lactate transport in heart and brain. Monocarboxylate transport via MCT2 was driven by the H(+) gradient over the plasma membrane. Uptake of lactate strongly increased with decreasing pH… CONTINUE READING
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