Characterization of the hepatitis C virus E2/NS1 gene product expressed in mammalian cells.

@article{Spaete1992CharacterizationOT,
  title={Characterization of the hepatitis C virus E2/NS1 gene product expressed in mammalian cells.},
  author={Richard R Spaete and David Alexander and M E Rugroden and Q L Choo and Kim Berger and Kevin R Crawford and C Kuo and Shuguang Leng and Cindy Lee and Robert Ralston},
  journal={Virology},
  year={1992},
  volume={188 2},
  pages={819-30}
}
Truncated and full-length versions of the hepatitis C virus protein domain encoding a presumptive envelope glycoprotein designated E2/NS1 were stably expressed in CHO cell lines. Characterization of the processing events involved in the maturation of E2/NS1 revealed that a high-mannose form resident in the endoplasmic reticulum was the most abundant form detected intracellularly. The ionophore carboxyl cyanide m-chlorophenyl-hydrazone was used to show that the E2/NS1 glycoprotein resided in the… CONTINUE READING

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