Characterization of the glutamatergic system for induction and maintenance of allodynia

  title={Characterization of the glutamatergic system for induction and maintenance of allodynia},
  author={T. Minami and S. Matsumura and E. Okuda-Ashitaka and K. Shimamoto and S. Ito},
  journal={Brain Research},
  • T. Minami, S. Matsumura, +2 authors S. Ito
  • Published 2001
  • Chemistry, Medicine
  • Brain Research
  • Glutamate is the main excitatory neurotransmitter in the central nervous system and has been shown to be involved in spinal nociceptive processing. We previously demonstrated that intrathecal (i.t.) administration of prostaglandin (PG) E(2) and PGF(2 alpha) induced touch-evoked pain (allodynia) through the glutamatergic system by different mechanisms. In the present study, we characterized glutamate receptor subtypes and glutamate transporters involved in induction and maintenance of PGE(2… CONTINUE READING
    75 Citations
    Characterization of N-methyl-D-aspartate receptor subunits responsible for postoperative pain.
    • 13
    Role of the spinal cord NR2B-containing NMDA receptors in the development of neuropathic pain
    • 129
    • PDF
    Functional characterization of prostaglandin F2α receptor in the spinal cord for tactile pain (allodynia)
    • 22
    The glutamate transporter GLAST is involved in spinal nociceptive processing.
    • 29
    Blockade of spinal glutamate recycling produces paradoxical antinociception in rats with orofacial inflammatory pain
    • 11


    Behavioral classification of excitatory amino acid receptors in mouse spinal cord.
    • 49
    Inhibition of uptake unmasks rapid extracellular turnover of glutamate of nonvesicular origin.
    • 311
    • PDF