Characterization of the gene for human plasminogen, a key proenzyme in the fibrinolytic system.

@article{Petersen1990CharacterizationOT,
  title={Characterization of the gene for human plasminogen, a key proenzyme in the fibrinolytic system.},
  author={Torben Ellebaek Petersen and Mark R Martzen and Akitada Ichinose and Earl W. Davie},
  journal={The Journal of biological chemistry},
  year={1990},
  volume={265 11},
  pages={6104-11}
}
The organization and structure of the gene coding for plasminogen has been determined by a combination of in vitro amplification of leukocyte DNA from normal individuals and isolation of unique clones from three different human genomic libraries. These clones were characterized by restriction mapping, Southern blotting, and DNA sequencing. The gene for human plasminogen spanned about 52.5 kilobases of DNA and consisted of 19 exons separated by 18 introns. DNA sequence analysis revealed that the… CONTINUE READING
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