Characterization of the gene cluster responsible for cylindrospermopsin biosynthesis.

  title={Characterization of the gene cluster responsible for cylindrospermopsin biosynthesis.},
  author={Troco Kaan Mihali and Ralf Kellmann and Julia Muenchhoff and Kevin D. Barrow and Brett A Neilan},
  journal={Applied and environmental microbiology},
  volume={74 3},
Toxic cyanobacterial blooms cause economic losses and pose significant public health threats on a global scale. Characterization of the gene cluster for the biosynthesis of the cyanobacterial toxin cylindrospermopsin (cyr) in Cylindrospermopsis raciborskii AWT205 is described, and the complete biosynthetic pathway is proposed. The cyr gene cluster spans 43 kb and is comprised of 15 open reading frames containing genes required for the biosynthesis, regulation, and export of the toxin… CONTINUE READING
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