Characterization of the functional domains of the SloR metalloregulatory protein in Streptococcus mutans.

@article{Haswell2013CharacterizationOT,
  title={Characterization of the functional domains of the SloR metalloregulatory protein in Streptococcus mutans.},
  author={Jeffrey R. Haswell and Benjamin W. Pruitt and Louis P Cornacchione and Christopher L. Coe and Evan G Smith and Grace A. Spatafora},
  journal={Journal of bacteriology},
  year={2013},
  volume={195 1},
  pages={126-34}
}
Streptococcus mutans is a commensal member of the healthy plaque biofilm and the primary causative agent of dental caries. The present study is an investigation of SloR, a 25-kDa metalloregulatory protein that modulates genes responsible for S. mutans-induced cariogenesis. Previous studies of SloR homologues in other bacterial pathogens have identified three domains critical to repressor functionality: an N-terminal DNA-binding domain, a central dimerization domain, and a C-terminal FeoA… CONTINUE READING
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