Characterization of the frameshift signal of Edr, a mammalian example of programmed −1 ribosomal frameshifting

@article{Manktelow2005CharacterizationOT,
  title={Characterization of the frameshift signal of Edr, a mammalian example of programmed −1 ribosomal frameshifting},
  author={Emily Manktelow and Kazuhiro Shigemoto and Ian Brierley},
  journal={Nucleic Acids Research},
  year={2005},
  volume={33},
  pages={1553 - 1563}
}
The ribosomal frameshifting signal of the mouse embryonal carcinoma differentiation regulated (Edr) gene represents the sole documented example of programmed -1 frameshifting in mammalian cellular genes [Shigemoto,K., Brennan,J., Walls,E,. Watson,C.J., Stott,D., Rigby,P.W. and Reith,A.D. (2001), Nucleic Acids Res., 29, 4079-4088]. Here, we have employed site-directed mutagenesis and RNA structure probing to characterize the Edr signal. We began by confirming the functionality and magnitude of… CONTINUE READING

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