Characterization of the first non-insect invertebrate functional angiotensin-converting enzyme (ACE): leech TtACE resembles the N-domain of mammalian ACE.

@article{Rivire2004CharacterizationOT,
  title={Characterization of the first non-insect invertebrate functional angiotensin-converting enzyme (ACE): leech TtACE resembles the N-domain of mammalian ACE.},
  author={Guillaume Rivi{\`e}re and Annie Michaud and Laurence Deloffre and Franck Vandenbulcke and Ang{\'e}lique Levoye and Christophe Breton and Pierre Corvol and Michel Salzet and Didier Vieau},
  journal={The Biochemical journal},
  year={2004},
  volume={382 Pt 2},
  pages={565-73}
}
Angiotensin-converting enzyme (ACE) is a zinc metallopeptidase that plays a major role in blood homoeostasis and reproduction in mammals. In vertebrates, both transmembrane and soluble ACE, containing one or two homologous active sites, have been characterized. So far, several ACEs from invertebrates have been cloned, but only in insects. They are soluble and display a single active site. Using biochemical procedures, an ACE-like activity was detected in our model, the leech, Theromyzon… CONTINUE READING
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