Characterization of the enzymatic activity of hChlR1, a novel human DNA helicase.

@article{Hirota2000CharacterizationOT,
  title={Characterization of the enzymatic activity of hChlR1, a novel human DNA helicase.},
  author={Yasushi Hirota and Jill M. Lahti},
  journal={Nucleic acids research},
  year={2000},
  volume={28 4},
  pages={917-24}
}
Recently, we cloned two highly related human genes, hChlR1 ( DDX11 ) and hChlR2 ( DDX12 ), which appear to be homologs of the Saccharomyces cerevisiae CHL1 gene. Nucleotide sequence analysis suggests that these genes encode new members of the DEAH family of DNA helicases. While the enzymatic activity of CHL1 has not been characterized, the protein is required for the maintenance of high fidelity chromosome segregation in yeast. Here we report that the hChlR1 protein is a novel human DNA… CONTINUE READING
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