Characterization of the endocannabinoid system in human spermatozoa and involvement of transient receptor potential vanilloid 1 receptor in their fertilizing ability.

@article{Francavilla2009CharacterizationOT,
  title={Characterization of the endocannabinoid system in human spermatozoa and involvement of transient receptor potential vanilloid 1 receptor in their fertilizing ability.},
  author={Felice Francavilla and Natalia Battista and Arcangelo Barbonetti and Maria Rosaria Caterina Vassallo and Cinzia Rapino and C Antonangelo and Nicoletta Pasquariello and Giuseppina Catanzaro and Barbara Barboni and Mauro Maccarrone},
  journal={Endocrinology},
  year={2009},
  volume={150 10},
  pages={4692-700}
}
Human spermatozoa express type-1 cannabinoid receptor (CB1), whose activation by anandamide (AEA) affects motility and acrosome reaction (AR). In this study, we extended the characterization of the AEA-related endocannabinoid system in human spermatozoa, and we focused on the involvement of the AEA-binding vanilloid receptor (TRPV1) in their fertilizing ability. Protein expression was revealed for CB1 ( approximately 56 kDa), TRPV1 ( approximately 95 kDa), AEA-synthesizing phospholipase D (NAPE… CONTINUE READING
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