Characterization of the elements and proteins responsible for interferon-stimulated gene induction by human cytomegalovirus.

@article{Yang2005CharacterizationOT,
  title={Characterization of the elements and proteins responsible for interferon-stimulated gene induction by human cytomegalovirus.},
  author={Shaojun Yang and James R Netterwald and Weijia Wang and Hua Zhu},
  journal={Journal of virology},
  year={2005},
  volume={79 8},
  pages={
          5027-34
        }
}
Human cytomegalovirus (HCMV) infection of human fibroblast cells activates a large number of interferon-stimulated genes (ISGs) in a viral envelope-cell membrane fusion-dependent mechanism. In this study, we identified two interferon response elements, the interferon-stimulated response element (ISRE) and the gamma interferon-activated site (GAS), which act as HCMV response sites (VRS). Gel mobility shift assays showed that cellular proteins form specific and identical complexes with ISRE and… CONTINUE READING

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