Characterization of the effects of receptor-selective ligands in rats discriminating the novel antipsychotic quetiapine

@article{Goudie2003CharacterizationOT,
  title={Characterization of the effects of receptor-selective ligands in rats discriminating the novel antipsychotic quetiapine},
  author={Andrew J. Goudie and Judith A. Smith and Mark John Millan},
  journal={Psychopharmacology},
  year={2003},
  volume={171},
  pages={212-222}
}
Drug discrimination studies with clozapine have shown that such assays are of value in analysing the actions of novel antipsychotic agents in vivo. To evaluate the role of specific receptors in the discriminative stimulus properties of the novel "atypical" antipsychotic quetiapine. Rats were trained to discriminate quetiapine at 10 mg/kg and tested with a range of ligands, selective for specific classes of receptor. Full generalization to quetiapine was only seen with quetiapine itself (100… CONTINUE READING
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