Characterization of the effects of gabapentin and 3-isobutyl-gamma-aminobutyric acid on substance P-induced thermal hyperalgesia.

@article{Partridge1998CharacterizationOT,
  title={Characterization of the effects of gabapentin and 3-isobutyl-gamma-aminobutyric acid on substance P-induced thermal hyperalgesia.},
  author={B J Partridge and Sandra R. Chaplan and Eiji Sakamoto and Tony L. Yaksh},
  journal={Anesthesiology},
  year={1998},
  volume={88 1},
  pages={196-205}
}
BACKGROUND The authors sought to characterize the pharmacologic characteristic and site of action of gabapentin (Neurontin) in a model of thermal hyperalgesia induced by intrathecal substance P administration. METHODS Rats were prepared with long-term lumbar intrathecal catheters. Hind paw withdrawal latency was determined using a radiant heat stimulus focused through a glass surface onto the plantar surface of the paw. RESULTS Within 5 min after intrathecal injection of substance P (30… CONTINUE READING

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