Characterization of the effector-specifying domain of Rac involved in NADPH oxidase activation.

@article{Kwong1995CharacterizationOT,
  title={Characterization of the effector-specifying domain of Rac involved in NADPH oxidase activation.},
  author={Christine Kwong and Anthony G Adams and Thomas L. Leto},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 34},
  pages={19868-72}
}
Production of microbicidal oxidants by phagocytic leukocytes requires activation of a latent NADPH oxidase by the coordinated assembly of a membrane-associated flavocytochrome b558, with three cytosolic components, p47phox, p67phox, and the low molecular weight GTP-binding protein Rac. Rac1 and Rac2 have 92% sequence identity and are both active in supporting the oxidase, while CDC42Hs, the closest relative to Rac with 70% sequence identity, only weakly supports oxidase activation in vitro. We… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

Molecular and Cellular Basis of Inflammation

Current Inflammation Research • 1999
View 5 Excerpts
Highly Influenced

Neutrophil Methods and Protocols

Methods in Molecular Biology • 2014

Similar Papers

Loading similar papers…