Characterization of the early steps of human parvovirus B19 infection.

@article{Quattrocchi2012CharacterizationOT,
  title={Characterization of the early steps of human parvovirus B19 infection.},
  author={Silva Quattrocchi and Nico Ruprecht and Claudia B{\"o}nsch and Sven Bieli and Christoph Zuercher and Klaus Boller and Christoph Kempf and Carlos Ros},
  journal={Journal of virology},
  year={2012},
  volume={86 17},
  pages={9274-84}
}
The early steps of human parvovirus B19 (B19V) infection were investigated in UT7/Epo cells. B19V and its receptor globoside (Gb4Cer) associate with lipid rafts, predominantly of the noncaveolar type. Pharmacological disruption of the lipid rafts inhibited infection when the drug was added prior to virus attachment but not after virus uptake. B19V is internalized by clathrin-dependent endocytosis and spreads rapidly throughout the endocytic pathway, reaching the lysosomal compartment within… CONTINUE READING

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