Characterization of the direct targets of FOXO transcription factors throughout evolution

@inproceedings{Webb2016CharacterizationOT,
  title={Characterization of the direct targets of FOXO transcription factors throughout evolution},
  author={Ashley E Webb and Anshul Kundaje and Anne Brunet},
  booktitle={Aging cell},
  year={2016}
}
FOXO transcription factors (FOXOs) are central regulators of lifespan across species, yet they also have cell-specific functions, including adult stem cell homeostasis and immune function. Direct targets of FOXOs have been identified genome-wide in several species and cell types. However, whether FOXO targets are specific to cell types and species or conserved across cell types and throughout evolution remains uncharacterized. Here, we perform a meta-analysis of direct FOXO targets across… CONTINUE READING
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