Characterization of the dihydrolipoamide dehydrogenase from Streptococcus pneumoniae and its role in pneumococcal infection

  title={Characterization of the dihydrolipoamide dehydrogenase from Streptococcus pneumoniae and its role in pneumococcal infection},
  author={A. W. Smith and H. Roche and Marie-Claude Trombe and D. Briles and A. Hakansson},
  journal={Molecular Microbiology},
  • A. W. Smith, H. Roche, +2 authors A. Hakansson
  • Published 2002
  • Biology, Medicine
  • Molecular Microbiology
  • In the present study, we have characterized the dihydrolipoamide dehydrogenase (DLDH) of Strepto‐coccus pneumoniae and its role during pneumococcal infection. We have also demonstrated that a lack of DLDH results in a deficiency in α‐galactoside meta‐bolism and galactose transport. DLDH is an enzyme that is classically involved in the three‐step conversion of 2‐oxo acids to their respective acyl‐CoA derivatives, but DLDH has also been shown to have other functions. The dldh gene was virtually… CONTINUE READING
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