Characterization of the differential coregulator binding signatures of the Retinoic Acid Receptor subtypes upon (ant)agonist action.

@article{Estruch2017CharacterizationOT,
  title={Characterization of the differential coregulator binding signatures of the Retinoic Acid Receptor subtypes upon (ant)agonist action.},
  author={Ignacio Miro Estruch and D. Melchers and R. Houtman and L. D. de Haan and J. Groten and J. Louisse and I. Rietjens},
  journal={Biochimica et biophysica acta. Proteins and proteomics},
  year={2017},
  volume={1865 9},
  pages={
          1195-1206
        }
}
Retinoic Acid Receptor alpha (RARα/NR1B1), Retinoic Acid Receptor beta (RARβ/NR1B2) and Retinoic Acid Receptor gamma (RARγ/NR1B3) are transcription factors regulating gene expression in response to retinoids. Within the RAR genomic pathways, binding of RARs to coregulators is a key intermediate regulatory phase. However, ligand-dependent interactions between the wide variety of coregulators that may be present in a cell and the different RAR subtypes are largely unknown. The aim of this study… Expand
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