Characterization of the designer benzodiazepine pyrazolam and its detectability in human serum and urine

@article{Moosmann2013CharacterizationOT,
  title={Characterization of the designer benzodiazepine pyrazolam and its detectability in human serum and urine},
  author={Bjoern Moosmann and Melanie Hutter and Laura M Huppertz and Sascha Ferlaino and Lisa Redlingsh{\"o}fer and Volker Auw{\"a}rter},
  journal={Forensic Toxicology},
  year={2013},
  volume={31},
  pages={263-271}
}
In 2012, online shops selling so-called research chemicals started offering pyrazolam, a new benzodiazepine that differs from phenazepam and etizolam, which have also recently appeared on the “gray market”, in that it is not marketed by pharmaceutical companies anywhere in the world. This article describes the characterization of pyrazolam (8-bromo-1-methyl-6-pyridin-2-yl-4H-[1,2,4]triazolo[4,3–a][1, 4]benzodiazepine) using gas chromatography-mass spectrometry, liquid chromatography-tandem mass… 
Detection and identification of the designer benzodiazepine flubromazepam and preliminary data on its metabolism and pharmacokinetics.
TLDR
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TLDR
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Human urinary metabolic patterns of the designer benzodiazepines flubromazolam and pyrazolam studied by liquid chromatography-high resolution mass spectrometry.
TLDR
This study performed to further investigate the human metabolic pattern of the NPS, or designer benzodiazepines flubromazolam and pyrazolam, and to propose analytical targets for urine drug testing of these substances.
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TLDR
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TLDR
Three benzodiazepines offered as 'research chemicals' on the Internet were characterized and their main in vitro phase I metabolites tentatively identified after incubation with pooled human liver microsomes, making a sufficient chromatographic separation inevitable.
Flubromazolam - Basic pharmacokinetic evaluation of a highly potent designer benzodiazepine.
TLDR
The presented data demonstrate the detectability of a single uptake of 0.5 mg of flubromazolam in hair samples collected two weeks after drug uptake by LC-MS3 (cmax 0.6 pg/mg; LOD 0.01 PG/mg).
Characterization of the four designer benzodiazepines clonazolam, deschloroetizolam, flubromazolam, and meclonazepam, and identification of their in vitro metabolites
TLDR
The characterization of these four designer benzodiazepines using nuclear magnetic resonance spectroscopy, gas chromatography–electron ionization-mass spectrometry, liquid chromatography-tandem mass spectrometric, liquid Chromatography–quadrupole time-of-flight-massSpectroscopy and infrared spectroscopic is presented.
MALDI-TOF mass spectrometric determination of eight benzodiazepines with two of their metabolites in blood.
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