Characterization of the currents induced by sigma ligands in NCB20 neuroblastoma cells

@article{Morio1994CharacterizationOT,
  title={Characterization of the currents induced by sigma ligands in NCB20 neuroblastoma cells},
  author={Y. Morio and H. Tanimoto and T. Yakushiji and Y. Morimoto},
  journal={Brain Research},
  year={1994},
  volume={637},
  pages={190-196}
}
Electrical and pharmacological properties of currents induced by compounds having affinities for putative sigma receptors were investigated with NCB20 cells by use of the whole-cell patch-clamp technique. Antipsychotics and naloxone induced inward currents with a decrease in membrane conductance at a holding potential of -60 mV. The rank order of potency for compounds inducing these currents was bromperidol > haloperidol > mosapramine = clocapramine > carpipramine > chlorpromazine > remoxipride… Expand
Sigma ligands stimulate the electrical activity of frog pituitary melanotrope cells through a G-protein-dependent inhibition of potassium conductances.
Membrane‐delimited coupling between sigma receptors and K+ channels in rat neurohypophysial terminals requires neither G‐protein nor ATP
The Sigma Receptor as a Ligand-Regulated Auxiliary Potassium Channel Subunit
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