Characterization of the cross-bridge force-generating step using inorganic phosphate and BDM in myofibrils from rabbit skeletal muscles.

@article{Tesi2002CharacterizationOT,
  title={Characterization of the cross-bridge force-generating step using inorganic phosphate and BDM in myofibrils from rabbit skeletal muscles.},
  author={Chiara Tesi and Francesco Colomo and Nicoletta Piroddi and Corrado Poggesi},
  journal={The Journal of physiology},
  year={2002},
  volume={541 Pt 1},
  pages={187-99}
}
The inhibitory effects of inorganic phosphate (P(i)) on isometric force in striated muscle suggest that in the ATPase reaction P(i) release is coupled to force generation. Whether P(i) release and the power stroke are synchronous events or force is generated by an isomerization of the quaternary complex of actomyosin and ATPase products (AM.ADP.P(i)) prior to the following release of P(i) is still controversial. Examination of the dependence of isometric force on [P(i)] in rabbit fast (psoas; 5… CONTINUE READING

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