Characterization of the cocaine binding site on the sigma-1 receptor.

@article{Chen2007CharacterizationOT,
  title={Characterization of the cocaine binding site on the sigma-1 receptor.},
  author={Yuenmu Chen and Abdol Reza Hajipour and Michael K Sievert and Marty Arbabian and Arnold E. Ruoho},
  journal={Biochemistry},
  year={2007},
  volume={46 11},
  pages={
          3532-42
        }
}
The cocaine photoaffinity label 3-iodo-4-azidococaine ([125I]IACoc) binds to the sigma-1 receptor with an affinity that is 2-3 orders of magnitude higher than the parent compound cocaine [Kahoun, J. R., and Ruoho, A. E. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 1393-1397]. In the present study, the binding properties of several cocaine derivatives to the guinea pig liver sigma-1 receptor were determined. The results from assessing the affinity of various derivatives of cocaine which were… CONTINUE READING
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