Characterization of the cloned atlantic cod neuropeptide Y-Yb receptor: peptide-binding requirements distinct from known mammalian Y receptors.

@article{Sharma1999CharacterizationOT,
  title={Characterization of the cloned atlantic cod neuropeptide Y-Yb receptor: peptide-binding requirements distinct from known mammalian Y receptors.},
  author={Pawan Sharma and Annette Arvidsson and A. Wraith and Annette G Beck-Sickinger and Ann Cathrine J{\"o}nsson-Rylander and Dan Larhammar},
  journal={General and comparative endocrinology},
  year={1999},
  volume={115 3},
  pages={422-8}
}
Five members of the neuropeptide Y (NPY) receptor family have been cloned in mammals. The recently cloned NPY receptor in the Atlantic cod seems to be distinct from the mammalian subtypes as it has only 50% identity to Y1, Y4, and y6 and only 30% to Y2 and Y5. In most of the other families of G-protein-coupled receptors, species homologues have 65-90% identity between fishes and mammals. The functional expression and detailed pharmacological characterization of this cod NPY receptor, designated… CONTINUE READING