Characterization of the clathrin heavy chain from Dictyostelium discoideum.

  title={Characterization of the clathrin heavy chain from Dictyostelium discoideum.},
  author={Theresa J. O'Halloran and Richard G. W. Anderson},
  journal={DNA and cell biology},
  volume={11 4},
We report the cloning and analysis of a clathrin heavy-chain cDNA from the eukaryotic microorganism, Dictyostelium discoideum. A single gene, designated chcA, for the clathrin heavy chain encoded a protein of 1,694 amino acids with a molecular mass of 193,618 daltons. Comparison of the amino acid sequence with the rat and with the yeast sequence showed that the highly conserved protein was more similar to the mammalian clathrin heavy chain (57% identity) than to the yeast heavy chain (45… CONTINUE READING

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