Characterization of the circuits that generate spontaneous episodes of activity in the early embryonic mouse spinal cord.

@article{Hanson2003CharacterizationOT,
  title={Characterization of the circuits that generate spontaneous episodes of activity in the early embryonic mouse spinal cord.},
  author={M. Gartz Hanson and Lynn T. Landmesser},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2003},
  volume={23 2},
  pages={587-600}
}
In the developing nervous system, patterned spontaneous activity affects a variety of developmental processes. Thus, it is important to identify the earliest time that such activity occurs and to characterize the underlying circuitry. In isolated mouse spinal cord-limb preparations, highly rhythmic spontaneous activity occurred as early as embryonic day 11 (E11)-E12, when many lumbosacral motoneurons were still migrating and extending their peripheral projections. This activity required both… CONTINUE READING
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