Characterization of the chicken C-type lectin-like receptors B-NK and B-lec suggests that the NK complex and the MHC share a common ancestral region.

@article{Rogers2005CharacterizationOT,
  title={Characterization of the chicken C-type lectin-like receptors B-NK and B-lec suggests that the NK complex and the MHC share a common ancestral region.},
  author={Sally L. Rogers and Thomas W. F. G{\"o}bel and Birgit C. Viertlboeck and S. Milne and Stephan Beck and Jim Kaufman},
  journal={Journal of immunology},
  year={2005},
  volume={174 6},
  pages={3475-83}
}
The sequencing of the chicken MHC led to the identification of two open reading frames, designated B-NK and B-lec, that were predicted to encode C-type lectin domains. C-type lectin domains are not encoded in the MHC of any animal described to date; therefore, this observation was completely unexpected, particularly given that the chicken has a "minimal essential MHC." In this study, we describe the initial characterization of the B-NK and B-lec genes, and show that they share greatest homology… CONTINUE READING

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