Characterization of the checkpoint gene RAD53/MEC2 in Saccharomyces cerevisiae.

Abstract

Saccharomyces cerevisiae cells carrying mutations in RAD53/MEC2 fail to arrest in the S phase when DNA replication is blocked (the S/M checkpoint) or in the G2 phase when DNA is damaged (the G2/M checkpoint). We isolated and determined the DNA sequence of RAD53 and found that it is identical to the SPK1 gene previously identified by Stern et al. (1991). In… (More)

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@article{Kim1997CharacterizationOT, title={Characterization of the checkpoint gene RAD53/MEC2 in Saccharomyces cerevisiae.}, author={S Kim and Ted A. Weinert}, journal={Yeast}, year={1997}, volume={13 8}, pages={735-45} }