Corpus ID: 16874159

Characterization of the changes in the levels of GABAergic and calcium channels markers in mice psychostimulant administration models

  title={Characterization of the changes in the levels of GABAergic and calcium channels markers in mice psychostimulant administration models},
  author={F. Su{\'a}rez},
The thalamocortical somatosensory system is the responsible for processing information coming from the sensory nerves so as to generate a somatosensory cognitive experience, which is the same, to produce a concrete sensation from the environment. This system consists of a highly coherent and differenced neuronal circuit, which allows perception to be carried on in our daily life. The alteration of the different components of the system by psychostimulants, such as cocaine or methylphenidate… Expand


Thalamocortical relationships and network synchronization in a new genetic model “in mirror” for absence epilepsy
The results show that the balance of the reciprocal connections between the thalamus and cortex is altered in favor of the corticothalamic connections in epileptic mice, and suggest that gap junctions mediate a stronger cortical synchronization in this strain. Expand
Thalamic circuitry and thalamocortical synchrony.
  • E. G. Jones
  • Biology, Medicine
  • Philosophical transactions of the Royal Society of London. Series B, Biological sciences
  • 2002
Differences in the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) subunit composition of receptors at synapses formed by branches of the same corticothalamic axon in the RTN and dorsal thalamus are an important element in the capacity of the cortex to synchronize low-frequency oscillations in the network. Expand
Effects of T-type calcium channel blockers on cocaine-induced hyperlocomotion and thalamocortical GABAergic abnormalities in mice
It is suggested that T-type calcium channels play a key role in cocaine-mediated GABAergic thalamocortical alterations, and is proposed as potential targets for future pharmacological strategies aimed at treating cocaine’s deleterious effects on physiology and behavior. Expand
Analysis of the role of the low threshold currents IT and Ih in intrinsic delta oscillations of thalamocortical neurons
A bifurcation analysis of a minimal conductance-based thalamocortical neuron model including only the IT channel and the sodium and potassium leak channels unveils the dynamics of repetitive burst firing of TC neurons, and describes how the interplay between the amplifying variable mT and the recovering variable hT of the calcium channel IT is sufficient to generate low threshold oscillations in the delta band. Expand
Cocaine Acute “Binge” Administration Results in Altered Thalamocortical Interactions in Mice
The data indicate that thalamocortical dysfunctions observed in cocaine abusers might be due to two distinct but additive events: increased low frequency oscillatory thalamOCortical activity, and overinhibition of VB neurons that can abnormally "lock" the whole thalamic relay ventrobasal system at low frequencies. Expand
Stimulation of dural vessels excites the SI somatosensory cortex of the cat via a relay in the thalamus
These findings may help to explain the ability of migraineurs with headache in the trigeminal distribution to localise their pain to a particular region in this distribution. Expand
Immunoreactivity for GAD and Three Peptides in Somatosensory Cortex and Thalamus of the Raccoon
The primary somatosensory cortex of the raccoon showed patterns of immunoreactivity for GAD and peptides that were similar to those of other species; the somatoensory thalamus revealed a distinctive profile of GAD immunore activity, with labeling that was light to moderate in the VPL/VPM complex and relatively extensive in VPL. Expand
GABAergic Neurons in Mammalian Thalamus: A Marker of Thalamic Complexity?
Thalamic GABAergic local circuit neurons are not directly related to the ability to perform specific sensorimotor tasks, but they are likely to reflect an increasing complexity of the local information processing that occurs at thalamic level. Expand
Ionic basis for the electro‐responsiveness and oscillatory properties of guinea‐pig thalamic neurones in vitro.
It is proposed that the intrinsic biophysical properties of thalamic neurones allow them to serve as relay systems and as single cell oscillators at two distinct frequencies, 9‐10 and 5‐6 Hz. Expand
Kynurenic Acid Is a Nutritional Cue that Enables Behavioral Plasticity
It is reported that kynurenic acid, a metabolite in this pathway, functions as a regulator of food-dependent behavioral plasticity in C. elegans, suggesting that a physiological role of kynUREnic acid is in directly linking metabolism to activity of NMDA and serotonergic circuits, which regulate a broad range of behaviors and physiologies. Expand