Characterization of the cathepsin-like cysteine proteinases of Schistosoma mansoni.

@article{Dalton1996CharacterizationOT,
  title={Characterization of the cathepsin-like cysteine proteinases of Schistosoma mansoni.},
  author={John Pius Dalton and K. A. Clough and Malcolm K Jones and Paul J. Brindley},
  journal={Infection and immunity},
  year={1996},
  volume={64 4},
  pages={
          1328-34
        }
}
Adult Schistosoma mansoni parasites synthesize and secrete both cathepsin L and cathepsin B cysteine proteinases. These cysteine proteinase activities, believed to be involved in hemoglobin digestion by adult schistosomes, were characterized by using specific fluorogenic peptide substrates and zymography. Both cathepsin L- and B-like activities with pH optima of 5.2 and 6.2, respectively, predominated in soluble extracts of worms, and both these activities were secreted by adult worms into the… CONTINUE READING

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