Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays.

Abstract

ADAM15 (a disintegrin and metalloproteinase 15) is a membrane-anchored metalloproteinase, which is overexpressed in several human cancers and has been implicated in pathological neovascularization and prostate cancer metastasis. Yet, little is known about the catalytic properties of ADAM15. Here, we purified soluble recombinant ADAM15 to test for its… (More)
DOI: 10.1042/BJ20082127

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