Characterization of the caspase cascade in a cell culture model of SOD1-related familial amyotrophic lateral sclerosis: expression, activation and therapeutic effects of inhibition.

@article{Sathasivam2005CharacterizationOT,
  title={Characterization of the caspase cascade in a cell culture model of SOD1-related familial amyotrophic lateral sclerosis: expression, activation and therapeutic effects of inhibition.},
  author={Sivakumar Sathasivam and Andrew James Grierson and Pamela J Shaw},
  journal={Neuropathology and applied neurobiology},
  year={2005},
  volume={31 5},
  pages={
          467-85
        }
}
  • Sivakumar Sathasivam, Andrew James Grierson, Pamela J Shaw
  • Published in
    Neuropathology and applied…
    2005
  • Biology, Medicine
  • There is increasing evidence that apoptosis or a similar programmed cell death pathway is the mechanism of cell death responsible for motor neurone degeneration in amyotrophic lateral sclerosis. Knowledge of the relative importance of different caspases in the cell death process is at present incomplete. In addition, there is little information on the critical point of the death pathway when the process of dying becomes irreversible. In this study, using the well-established NSC34 motor neurone… CONTINUE READING

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