Characterization of the bupropion cue in the rat: Lack of evidence for a dopaminergic mechanism

  title={Characterization of the bupropion cue in the rat: Lack of evidence for a dopaminergic mechanism},
  author={Robert D. Blitzer and Robert E. Becker},
Using a two-lever operant task rats were trained to discriminate 40 mg/kg IP of bupropion from saline. Despite bupropion's established dopaminergic activity in vitro and in vivo, it was found that the bupropion cue was neither mimicked by the dopaminergic drugs l-DOPA and bromocriptine nor blocked by a variety of neuroleptics (haloperidol, thioridazine, and thiothixene). In addition, bupropion was active in attenuating the behavior-suppressing effects of haloperidol, unlike amphetamine and the… CONTINUE READING


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