Characterization of the breakpoints in a t(8;13)(p11;q12) translocation from a patient with myeloproliferative disease using fluorescence in situ hybridization.

@article{Chernova1998CharacterizationOT,
  title={Characterization of the breakpoints in a t(8;13)(p11;q12) translocation from a patient with myeloproliferative disease using fluorescence in situ hybridization.},
  author={Olga B. Chernova and Ivan H. Still and Matt E. Kalaycio and Gerald A. Hoeltge and John K Cowell},
  journal={Genes, chromosomes & cancer},
  year={1998},
  volume={21 2},
  pages={160-5}
}
We used fluorescence in situ hybridization to characterize the molecular position of the breakpoints in a t(8;13)(p11;q12) reciprocal translocation from a patient with an atypical myeloproliferative disorder. This structural chromosome abnormality is characteristic of this specific disease and occurs often as the only chromosome abnormality in the malignant cells. Yeast artificial chromosome (YAC) analysis has demonstrated that the 8p11 breakpoint lies within a region defined by YAC 959A4 and… CONTINUE READING

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