Characterization of the bombesin receptor on mouse pancreatic acini by chemical cross-linking

@article{Huang1990CharacterizationOT,
  title={Characterization of the bombesin receptor on mouse pancreatic acini by chemical cross-linking},
  author={Suming Huang and Dr. Hairong Yu and Stephen Wank and Jerry Gardner and Robert Thomas Jensen},
  journal={Peptides},
  year={1990},
  volume={11},
  pages={1143-1150}
}
Bombesin (BN), gastrin-releasing peptide (GRP) and GRP(18-27) (neuromedin C) were equipotent and 30-fold more potent than neuromedin B (NMB) in inhibiting binding of 125I-GRP to and in stimulating amylase release from mouse pancreatic acini. In the present study we used 125I-GRP and chemical cross-linking techniques to characterize the mouse pancreatic BN receptor. After binding of 125I-GRP to membranes, and incubation with various chemical cross-linking agents, cross-linked radioactivity was… CONTINUE READING
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