Characterization of the biosynthetic gene cluster for cryptic phthoxazolin A in Streptomyces avermitilis

Abstract

Phthoxazolin A, an oxazole-containing polyketide, has a broad spectrum of anti-oomycete activity and herbicidal activity. We recently identified phthoxazolin A as a cryptic metabolite of Streptomyces avermitilis that produces the important anthelmintic agent avermectin. Even though genome data of S. avermitilis is publicly available, no plausible… (More)
DOI: 10.1371/journal.pone.0190973

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