Characterization of the binding and internalization of tetanus toxin in a neuroblastoma hybrid cell line.

@article{Staub1986CharacterizationOT,
  title={Characterization of the binding and internalization of tetanus toxin in a neuroblastoma hybrid cell line.},
  author={Gregory Staub and Kevin M. Walton and Ronald L Schnaar and T. Everett Nichols and R. R. Baichwal and Kathryn A. Sandberg and Terry Rogers},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1986},
  volume={6 5},
  pages={
          1443-51
        }
}
Tetanus toxin is known to bind neuronal tissue selectively. To study the interactions of this potent neurotoxin in an intact cell system, the binding of 125I-tetanus toxin was characterized in a neuroblastoma retina hybrid cell line, N18-RE-105. The binding of 125I-tetanus toxin to membranes prepared from N18-RE-105 cells showed many similarities to the interactions of 125I-toxin with rat synaptic membranes. The binding was decreased with increasing temperature, ionic strength, and pH. 125I… CONTINUE READING

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