Characterization of the basic fibroblast growth factor-evoked proliferation of the human Müller cell line, MIO-M1

@article{Hollborn2004CharacterizationOT,
  title={Characterization of the basic fibroblast growth factor-evoked proliferation of the human M{\"u}ller cell line, MIO-M1},
  author={Margrit Hollborn and Karsten Jahn and Gloria Astrid Limb and Leon Kohen and Peter Wiedemann and Andreas Bringmann},
  journal={Graefe's Archive for Clinical and Experimental Ophthalmology},
  year={2004},
  volume={242},
  pages={414-422}
}
Basic fibroblast growth factor (bFGF) has been suggested to mediate activation of Müller glial cells in the ischemic–hypoxic retina. However, the intracellular pathways activated by bFGF in human Müller cells have been little explored. We characterized the signaling transduction pathways which are involved in the control and growth factor-evoked proliferation of a recently described human Müller cell line, MIO-M1. In addition, we investigated whether bFGF evoked the release of vascular… CONTINUE READING