Characterization of the antiparkinsonian effects of the new adenosine A2A receptor antagonist ST1535: acute and subchronic studies in rats.

@article{Tronci2007CharacterizationOT,
  title={Characterization of the antiparkinsonian effects of the new adenosine A2A receptor antagonist ST1535: acute and subchronic studies in rats.},
  author={Elisabetta Tronci and Nicola Simola and Franco Borsini and Nicoletta Schintu and Lucia Frau and Paolo Carminati and Micaela Morelli},
  journal={European journal of pharmacology},
  year={2007},
  volume={566 1-3},
  pages={94-102}
}
Antagonism of adenosine A2A receptor function has been proposed as an effective therapy in the treatment of Parkinson's disease. Thus, the study of new adenosine receptor antagonists is of great importance for the potential use of these drugs in clinical practice. The present study evaluated effects of the new preferential adenosine A2A receptor antagonist 2-butyl-9-methyl-8-(2H-1,2,3-triazol-2-yl)-9H-purin-6-ylamine (ST1535) in unilaterally 6-hydroxydopamine lesioned rats. Acute ST1535 dose… CONTINUE READING

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