Characterization of the antinociceptive effects of TRK-820 in the rat.

  title={Characterization of the antinociceptive effects of TRK-820 in the rat.},
  author={Takashi Endoh and Akihiko Tajima and Tsutomu Suzuki and Junzo Kamei and Minoru Narita and Leon Fu Tseng and Hiroshi Nagase},
  journal={European journal of pharmacology},
  volume={387 2},
We have already reported that TRK-820, (-)-17-cyclopropylmethyl-3, 14b-dihydroxy-4, 5a-epoxy-6b-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan hydrochloride, a new selective kappa-opioid receptor agonist, has affinity for kappa-subtype opioid receptors other than the kappa(1)-opioid receptor. It would be of interest to examine whether the different kappa-opioid receptor subtype properties of TRK-820 participate in its antinociceptive action in the inflamed paw test and the formalin test. TRK… CONTINUE READING