Characterization of the antigenic, immunogenic, and pathogenic variation of infectious bursal disease virus due to propagation in different host systems (bursa, embryo, and cell culture). III. Pathogenicity.

@article{RodriguezChavez2002CharacterizationOT,
  title={Characterization of the antigenic, immunogenic, and pathogenic variation of infectious bursal disease virus due to propagation in different host systems (bursa, embryo, and cell culture). III. Pathogenicity.},
  author={Isaac R Rodriguez-Chavez and John K. Rosenberger and Sandra S Cloud and Conrad R. Pope},
  journal={Avian pathology : journal of the W.V.P.A},
  year={2002},
  volume={31 5},
  pages={
          485-92
        }
}
Differences in the relative pathogenicity of variant (1084 E and GLS) and standard (Edgar and STC) infectious bursal disease virus (IBDV) strains were observed after propagation in the bursa of Fabricius, embryos, or cell cultures. Bursa-derived IBDV induced the most severe lesions in the bursa of Fabricius when compared with strains propagated in embryos or cell cultures. Embryo-derived IBDV induced moderate gross bursal lesions, whereas cell culture-derived IBDV did not damage the bursa… CONTINUE READING