Characterization of the antibody response in mice with type II collagen-induced arthritis, using monoclonal anti-type II collagen antibodies.

@article{Holmdahl1986CharacterizationOT,
  title={Characterization of the antibody response in mice with type II collagen-induced arthritis, using monoclonal anti-type II collagen antibodies.},
  author={Rikard Holmdahl and Kristofer Rubin and Lars Klareskog and E. -L. Larsson and Hans Wigzell},
  journal={Arthritis and rheumatism},
  year={1986},
  volume={29 3},
  pages={400-10}
}
Twenty monoclonal antibodies reactive with type II collagen were characterized as to their determinant specificity and their reactivity with cartilage-derived components. The monoclonal antibodies reacted with 7 different epitopes on the native type II collagen triple helical structure. Antibodies defining 3 of these epitopes occurred more frequently in sera from arthritic mice than in sera from nonarthritic mice. In vivo injection of some selected autoreactive antibodies caused synovitis, but… CONTINUE READING

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