Characterization of the androgen-sensitive MDA-kb2 cell line for assessing complex environmental mixtures.

@article{Blake2010CharacterizationOT,
  title={Characterization of the androgen-sensitive MDA-kb2 cell line for assessing complex environmental mixtures.},
  author={Lindsey S Blake and Dalma Martinovic and Leon Earl Gray and Vickie S Wilson and Ron R Regal and Daniel L. Villeneuve and Gerald T. Ankley},
  journal={Environmental toxicology and chemistry},
  year={2010},
  volume={29 6},
  pages={1367-76}
}
Synthetic and natural steroidal androgens and estrogens and many other non-steroidal endocrine-active compounds commonly occur as complex mixtures in aquatic environments. It is important to understand the potential interactive effects of these mixtures to properly assess their risk. Estrogen receptor agonists exhibit additivity in mixtures when tested in vivo and in vitro. Little is known, however, concerning possible mixture interactions of androgen receptor agonists. In these studies we used… CONTINUE READING