Characterization of the adenylation site in the RNA 3'-terminal phosphate cyclase from Escherichia coli.

@article{Billy1999CharacterizationOT,
  title={Characterization of the adenylation site in the RNA 3'-terminal phosphate cyclase from Escherichia coli.},
  author={Eric Billy and Daniel Hess and Jan Hofsteenge and W. Filipowicz},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 49},
  pages={34955-60}
}
RNA 3'-terminal phosphate cyclases are a family of evolutionarily conserved enzymes that catalyze ATP-dependent conversion of the 3'-phosphate to the 2',3'-cyclic phosphodiester at the end of RNA. The precise function of cyclases is not known, but they may be responsible for generating or regenerating cyclic phosphate RNA ends required by eukaryotic and prokaryotic RNA ligases. Previous work carried out with human and Escherichia coli enzymes demonstrated that the initial step of the… CONTINUE READING
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